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Zack may refer to:
- Zack, fifth-grader at Springfield Elementary
- Zachary Vaughn, Mrs. Krabappel's temporary replacement as fourth grade teacher
- Zack (Springfield Retirement Castle), Abraham Simpson's rival for the affections of Zelda
- Zack (Sneakers), one of the producers of the reality show Sneakers
- Norbert "Zack" Van Houten, Milhouse's cool uncle