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- Wile E. Coyote is a cartoon character from the Looney Tunes series of cartoons, whose sole purpose in life is to catch and dispatch the Road Runner consistently and constantly failing in his efforts
- The start of Wile E.'s cartoons were parodied in the episodes "The Scorpion's Tale" (with a real Roadrunner & coyote) & "Homer Alone" (with Homer & Bart)
- In "The Itchy & Scratchy & Poochie Show", June Bellamy said she used to act on his show as his enemy Road Runner.