The episode title is a pun on the 2000 romantic comedy film What Women Want, which starred Mel Gibson and Helen Hunt.
The opening couch gag is a reference to the popular television show Breaking Bad, along with the song "Crystal Blue Persuasion", which is used occasionally on Breaking Bad. Bryan Cranston and Aaron Paul, who star in Breaking Bad, were seen in a life action bit at the end of the couch gag.
When Milhouse is throwing cupcakes to get Lisa's attention, she opens her window with the right window pane going behind the left (which should have scraped/moved the cupcakes off the right side of her window). When the screen changes points of view, the left pane is behind the right instead.
In one frame, one of Milhouse's eyebrows is red.
Lisa is barefoot in bed when Milhouse throws cupcakes at her window. Her feet are bigger than they usually are.