When Homer says "No one's ever been killed by a t-shirt canon", a t-shirt is fired into the Flanders' house, breaking the picture of Maude Flanders. Ned looks directly at the audience after the picture breaks since she was killed by that very device in "Alone Again, Natura-Diddily".
When the president of Duff Beer says, "With great taste comes great responsibility", it is a reference to the famous "with great power there must also come great responsibility" line spoken by Ben Parker, uncle of Peter Parker/Spider-Man.
The song that plays during several of the scenes is P!nk's "Get the Party Started".
The end credits include a clip of Sam Simon describing his work, with a thank-you to him. Simon had died the week before on March 8, 2015.
Homer is tapped as Duffman's replacement, although previous episodes. like "Marge and Homer Turn a Couple Play" have shown there to be more than one actor playing Duffman.
This is one of the episode to have Duffman make a major appearance.
The intro advert for Homer as Duffman is a parody of the hit fantasy HBO show Game of Thrones and later Homer does a oath that parodies the Night Watches oath.
When the flight attendant says they are out of fuel, the propellers of the Duff Blimp are still working.