The Moody Blues were the opening act for the Nights and White Satin playing Moody Blues songs.
Lisa briefly referenced the events of "Trash of the Titans" when she remarked that she was surprised that they allowed the Casino to come along when they moved the city.
Ned references the theme tune to the sitcom "Maude" when he proclaims, "And then there's Maude!"
Ned is revealed to be 60. His voice actor, Harry Shearer turned 60 four years after the episode first aired.
When Homer laughs at Ned after finding out he married Ginger, he and Ned were standing in the hot tub, but when Homer screams after finding out he married Amber almost a second later, they were suddenly standing out of it.
Homer worries that he committed bigamy by marrying Amber, but "Wedding For Disaster" later revealed that Reverend Lovejoy's license to wed couples was null and void, meaning that Homer's divorce from "A Milhouse Divided" still stood and Homer's marriage to Amber was legal.
On the premiere episode (and the syndicated reruns), Homer mutters that Barney Gumbel's birthday is the same day as Adolf Hitler's (April 20th). Because the Columbine school shooting happened on that day, the line on the UK version and the season 10 DVD set is changed to "Barney's birthday is July 15th, same day as Lassie's."
The 2009 film "The Hangover" is a ripoff of this episode.
The title of the episode is a reference to the film and song Viva Las Vegas.
The chalkboard gag references Jerry Seinfeld.
While driving in the desert, author and journalist Hunter S. Thompson and his lawyer pass Ned and Homer in the oncoming lane, drawn in the style of the Ralph Steadmann painting, The Savage Journey. This is a reference to the Hunter S. Thompson novel, Fear and Loathing in Las Vegas.
Jeffery Albertson's bumper stickers include a series of sci-fi references, including Star Trek ("I Brake for Tribbles", "My Child is an Honor Student at Starfleet Academy" and "Keep Honking, I'm Charging My Phaser"), Star Wars ("My Other Car is the Millennium Falcon") and The X-Files ("The Truth is in Here"), as well as The Simpsons itself ("Kang Is My Co-Pilot").
On the church marquee, the text says "TODAY'S TOPIC: He knows what you did last summer." This may be a reference to the 1997 movie I Know What You Did Last Summer, which is based on the 1973 novel of the same name.
When Homer and Ned are getting married, the preacher says "the power invested in me by the Chicago Outfit". The Chicago Outfit is a Italian-American Mafia group based in Chicago, with resources and territory in Las Vegas. Perhaps its most famous member is Alphonse "Al" "Scarface" Capone, which was its boss from the 1920s all the way up until 1932, when he was arrested for tax evasion.