This is the first Treehouse of Horror episode to have a character directly reference in one segment the events of another segment (Homer expresses regret that he gave up on his Death powers regarding Frinkenstein upon witnessing his actions).
This episode marks the second time Homer was cast to be a Marvel Comics character (which also was a beast-like character); the first time was in "I Am Furious (Yellow)", where he lost his temper and temporarily acted as The Incredible Hulk.
Referring to the remark about Homer talking about the previous episode, this also sort of happens in "Treehouse of Horror XII," where the Leprechaun from the first story, "Hex and the City", is seen on Bart's back in the "Wiz Kids" segment.
The scene where Professor Frink kicks his father in the crotch is similar to the second Scooby-Doo movie, where Velma kicks the Black Knight ghost in the crotch, saying it was his "weak spot". The film was released four months after the episode aired.
The Beverely Hillbillies After Professor Frink showed Lisa Simpson a clip from The Beverely Hillbillies he removed Elly May and Granny's clothes. After that Granny told Elly May that she had some bad news, Jethro had ate her monkey.
After first freezing Lisa, Bart says "Wow, she looks like a background character from a Hanna-Barbera cartoon". Referencing that background characters in cartoons are often still and motionless.
The scene where Death is chasing the Simpson family in the upstairs of their house is similar to the Scooby-Doo characters being chased through a set of rooms.
Jerry Lewis reprised his role from The Nutty Professor.
Father like Frankenstein harvesting organs, but from living people. First he bumps into is jogging Ned Flanders asking him "Who are you, the 700 Club from this film.
The bobble head Simpson family are like the bobble head universe from the Futurama episode The Farnsworth Parabox, 4ACV15.
The scene where Professor Frink kicks his father in the crotch is similar to the second Scooby-Doo movie, where Velma kicks the Black Knight ghost in the crotch, saying it was his "weak spot".
Jerry Lewis voices a "he-man scientist" who bears a striking physical resemblance to Doc Savage from Doc Savage: The Man of Bronze.
One of the comics Bart pulls out is titled ‘Batman and Rhoda’. Julie Kavner played Rhoda’s sister, Brenda, on the show.
When Bart and Lisa begin fighting, the pile of candy disappears from the carpet.
When Homer is going down to get some better seats at the game, everyone he touches dies. However, a man blocks Homer from touching his forehead he survives.
At the begining of the segment Professor Frink states that his father no longer has a penis. However later on in the segment Professor Frink kicks him in the "balls" (penis), it is never mentioned that Professor Frink's father had gotten a penis in some way, this however could be just a simple mistake.
Stop the World, I Want to Goof Off
When the Simpsons are hula-hooping, Bart moves from the floor to his bed.
When Lisa uses the stopwatch at the end Bart changes back from his 25 year old self back to his 10 year old self without explanation.