The band playing at New Year's Rockin' Eve is actually Ratt according to the drumset, though the band members thought they were either Quiet Riot, Poison or Whitesnake.
Lisa being crushed by the bleacher with only her feet being shown is a reference to The Wizard of Oz when Dorothy's house crushes the wicked witch of the east.
In the third segment, Ned is wearing "Beatle Boots", which references that he was a fan of the Beatles before "The Bart of War".
This is one of two episodes of this season where the Simpsons accidentally run over a character, getting caught, and the victim turning out to be still alive. The other one being "Kill the Alligator and Run".
This is the ninth Treehouse of Horror to have the cast's names changed due to Halloween (e.g. Bat Groening). The first eight were from Treehouse of Horror episodes II-IX.
Some of the names The Collector wishes for Lucy to name him on their wedding night are: Obi-wan, Iron Man, Mr. Mxyzptlk and Big Papa Smurf.
The way Ned writes "I know what you did" on the walls, it's a reference to Treehouse of Horror V when Homer wrote "No TV and no beer make Homer go crazy."
The is the last Treehouse of Horror episode to have a couch gag until XXIV in Season 25.
Marge reminds Bart and Lisa that they are vulnerable to kryptonite, the same weakness the DC Comics superhero Superman is vulnerable to.
When Homer pokes the supposedly dead Flanders, he pokes him through the lenses of his spectacles.
If Lisa was excepted to escape from Earth and go to Mars, how come she didn't get a letter? They could have left the house in such a hurry they didn't check the mailbox.
When the Simpsons were inspecting their roadkill you can see Flanders' sleeves intact. In the flashback story of Flanders when he finally caught up with the Simpsons after their car broke down, you can see that Flanders's sweater sleeves are ripped due to his lycanthropic metamorphosis.
Stretch Dude was able to punch through the collector's base wall, but only Clobber Girl has super strength.