Tomacco is the produce made by Homer, when mixing Tobacco and Tomatoes after putting a plutonium rod in the ground near the tobacco and tomato plants.
A tobacco company bought it as it seemed to be legal, but Lisa did not approve because it killed consumers.
When Homer Simpson was selling it, all the animals ate it and became addicted to it. They became violent, and would do anything to get it. Everyone hates the Tomacco but keeps eating it because of the nicotine in the tobacco. It looks like a tomato on the outside but inside it is the brown, flaky tobacco.
In "The Simpsons: Hit and Run", a billboard can be seen over a Tomacco field. It is also implied that Cletus Spuckler grew tomacco for the market in Level 1's bonus mission as well as Mission 4 where it was revealed that a crop circle emerged.
- In the new high definition opening sequence, Maggie is on the store conveyor belt alongside a bottle of Tomacco Juice.
- Ralph claimed that tomacco "tastes like grandma".
- Inspired by Homer's accident, Rob Baur of Lake Oswego, Oregon attempted to create his own Tomacco Plant through grafting instead of radiation. The resulting plant survived while producing fruit for more than a year.