The Americans QB is a parody of Tom Brady, the coach is a parody of Bill Belichick, Domp Bonkowski is a parody of Rob Gronkowski, the mascot is a parody of Pat Patriot, and the scandals are parodies of headsets and Spygate respectively.
Boston Americans is the former name of the Boston Red Sox baseball team.
The movie The Departed is mentioned a few times in the episode.
Bart (wearing a blue cap) is intimidated by Apu and Sideshow Mel (wearing red clothes). This is a reference to the rivalry between the gangs Crips (identified by their blue clothing) and the Bloods (identified by their red clothing).
When Homer says that The Springfield Atoms were relocated from Portland, it could be a knock at the Indianapolis Colts, which used to be located in Baltimore.
Regional references to the Massachusetts area:
Newbury Comics-esque stickers adorn the wall of the tunnel and the neighborhood Lisa and Bart walk through.
Bart's comment about Boston Americans' victory parades being a state holiday has a minor ring of truth to it: from 2001 through the episode's original airing in 2016 there have been nine sports victory parades in the city--four for the Patriots, three for the Red Sox, and one each for the Boston Bruins and Boston Celtics--and one commentator on the morning show for local radio station WROR stated that children were beginning to erroneously believe that victory parades were an annual event.
Two Boston Celtics jokes, as the Celtics are the city's most victorious sports team with 17 championships as of the episode's original 2016 airing