The Homer, the car that was built for Homer by Herbert Powell, is unlocked when you complete all 10 missions in the game. Also, when highlighted, Homer will say, "The sticker price is... $82,000?!"
In print ads for The Simpsons Road Rage, it depicted a drawn panel similar to a comic where the entire town is in calamity, with Marge, acting as a passenger to Homer in a convertible, tells him with fear that he is driving like a maniac, and Homer responding non-chalantly that "Driving's just a suggestion. Like pants."
Goof:Willie's eyes flash green before he is picked up and after he is dropped off.
Joe Quimby can say "You drive worse than cousin Teddy!" if his driver is behaving chaotically. This is a reference to the Chappaquiddick Incident, where Mary Jo Kopechne, a female passenger of Ted Kennedy, was killed when he accidentally drove his car off a bridge.
Krusty the Clown can, if driven to his destination fast, say "That ride was over faster than Chevy Chase's talk show!". The Chevy Chase Show, a talk show hosted by actor and comedian Chevy Chase, lasted only five weeks.
Similarly, Krusty the Clown can, if his ride drives terribly and/or is late, make a negative comparison to Mickey Rooney regarding driving skills.
Marge Simpson can, if driven to her destination fast, say "You're a better driver than Jeff Gordon!". Jeff Gordon is a professional race car driver.
In the Xbox/PS2/GameCube ending, Mr. Burns, while ranting about Springfield's successfully buying back the public transit system, references the Summer of Love when stating that it was the worst display of civil disobedience he had ever witnessed.
In the GBA ending, as the curtains close, Homer will end up spazzing out, which may be a reference to his wigging out upon eating Focusyn-laced candy.
Due to gameplay mechanics in the Xbox/PS2/GameCube versions of the game, some of the exchanges between the passengers and player character will sometimes come across as out of character for the driver:
If the player is playing as Apu and picks up either Nelson or one of the bullies and their requested destination was the Kwik-E-Mart, he will gladly take them there, despite them openly admitting to planning to either vandalize or otherwise shoplift the storefront.
If the player is playing as either Bart, Lisa or Marge, and picks up Snake with the destination being 742 Evergreen Terrace, they will gladly take him there, despite his openly admitting to planning to loot the house.