Hit & Run, inspired by the Grand Theft Auto series, shares some similarities with the game, including the radar, and a strong focus on its driving aspect. Chief Wiggum mentions Grand Theft Auto if the player attempts to get into the police car on his side.
Similar to Road Rage, occasionally if the player loses a mission in one of Homer's chapters, Homer will say "This video game suh-ucks!", which is the same line Barry Badger stated when losing in Crash Tag Team Racing. All three games were also made by Radical Games.
The music that plays during the mission "Long Black Probes" is a remix of the theme music from the TV series "UFO".
In the scripts folder of the game files, there are level folders going up to level 9 (although level 8's and level 9's are empty). It is unknown what levels 8 and 9 were like.
In the fifth level, the popsicle stick sky scraper is no longer there, it has been burnt down.
The Radical Entertainment logo had been changed exclusively in this game. It sounds like a wasp camera filming a ball going up and down and Snake Jailbird helps by saying "Woah, Radical!". This is the only Simpsons game to do this.
Chief Wiggum attempts to nail Snake through the "Three Strikes Law", which was earlier used as the reason for Snake's execution in Treehouse of Horror IX. However, unlike the episode that the Three Strikes Law was used in, the consequence under the three strikes law was not execution, as Snake reappeared in Apu's level under "community service."
The observatory and the Springfield Sign are close in the game, yet the series shows that they are on opposite sides of the town to each other, also the Springfield Sign is not anywhere near a bridge it is behind the power plant