The Missionary Lady is a passenger on Busman's School Bus in Nowheresville.
History
Busman takes her to Garlicville. Busman mentions that she's hoping to meet up with her husband (presumably Ned Flanders) to preach to the 'heathens' in the city. While being attacked by Mutant Vampires she is able to scare one of them from the bus with her cross.[2]