For an anniversary gift, Homer gives Marge a Koi Pond for the backyard. The new pond attracts a caterpillar that constantly screams, and Homer is about to kill it. However, an EPA agent appears out of nowhere and tells them that the caterpillar is a Screamapillar and is an endangered species. By law, the Simpsons are responsible for the Screamapillar's well-being because it has chosen to take up residence in their pond. When Homer believes he has accidentally killed the insect, he tries to hide what happened, but the EPA returns and apprehends him. The Screamapillar is safe, but Homer is convicted of "attempted insecticide" and "aggravated buggery" and is sentenced to 200 hours of community service.
For his community service, Homer delivers Meals on Wheels and is frightened when one of his elderly clients appears to be threatening him with an axe. It turns out she is just a kindly old woman, Myrna Bellamy, and she asks Homer to join her for some company. She also says she only needs the axe to cut the Meals on Wheels steaks. Homer feels sorry for Myrna because she is a lonesome old woman, and starts lending her a hand around her house. Very soon, she seems to be taking advantage of Homer's kindness as Homer starts spending more and more time at her house. Marge becomes annoyed because Homer is spending less time with her and the kids and confronts Myrna, but then quickly finds herself guilt-tripped into helping the old woman as much as Homer has been. Both of them come to resent being manipulated into becoming, in effect, Myrna's personal servants.
When Myrna turns up dead (stabbed with a pair of scissors) and her diamond necklace is stolen, Homer and Marge are considered top suspects—especially when it is discovered that Myrna had just recently changed her will to leave them $50,000. Homer and Marge suspect a man with braces, whom they saw leaving the scene with the necklace. Everyone else suspects Marge and Homer, and the townspeople are scared of them to the point where Homer gets free drinks from Moe just by implying that he might kill someone, and also easily intimidates Reverend Lovejoy into cutting his sermon short. When the police search the Simpson home and find the necklace, Homer and Marge are arrested.
The children are sent to a yokel foster home, and Marge and Homer are put on trial for Myrna's murder. With Gil as their lawyer, they don't have a chance, and they are quickly convicted and sentenced to death in the electric chair. When Homer realizes that Marge is going to miss the kids, he confesses to being solely responsible for the crime, which allows Marge to be released. Homer is strapped into the chair and about to be executed when it is revealed he is a participant on a new reality TV show called "Frame Up." The man with the braces is the host. As for Myrna, she is still alive, and isn't an old woman at all, but actually co-host Carmen Electra in disguise.
Homer is quickly freed and reunited with his family. Chief Wiggum is relieved that he won't have to carry out Homer's execution, but protests about the show's forcing him to use all of the time and resources of the Police Department on what turned out to not even be a real case, until he realizes he will be on TV—at which point he tries to get Lou and Eddie producer credits. Homer, for his part, is thoroughly disgusted. He lectures Carmen Electra about the callousness of toying with people's lives for the sake of TV ratings, when she interrupts him: "Homer? My face is up here." He has been looking at her breasts the entire time he has been talking to her. Homer says, "I've made my choice," and continues staring her in the breasts.