Springfield High School is the town's main high school. One current student is the Squeaky-Voiced Teen. They have an air-hockey table. The building resemblances the real-life Grant High School in Portland, Oregon.
As well as being a school, they have hosted events there. One such event was a ballet performance, despite the fact there was a gas leak in the school.
- Harlan Dondelinger, the principal
- Ms. Bloomenstein, a teacher
- Coach Flanagan, a basketball coach
- Mr. Seckofsky, a shop teach
- Mr. Schindler, an art teacher
- A-L Counselor, a school guidance counselor
- M-Z Counselor, a school guidance counselor
- Homer Simpson
- Marge Bouvier
- Barney Gumble
- Artie Ziff
- Waylon Smithers
- Lenny Leonard
- Carl Carlson
- Chloe Talbot
- Marge's friend
- Bobby Mindix
- Snake Jailbird
- Edna Krabappel
- Clancy Wiggum
- Madam Wu
Due to the lack of recurring teenagers in the series, and that most of the school plots revolve around Bart and Lisa at Springfield Elementary School, the only known teenager who attend Springfield High School is:
- Bart Simpson
- Lisa Simpson
- Milhouse Van Houten
- Nelson Muntz
- Martin Prince
- Ralph Wiggum
- Janey Powell
- Üter Zörker
- Wendell Borton
- Allison Taylor
- Episode – "The Way We Was"
- Episode – "The Front" (Mentioned)
- Episode – "Homer Goes to College"
- Episode – "Marge on the Lam"
- Episode – "Who Shot Mr. Burns? (Part One)" (Mentioned)
- Episode – "Homerpalooza"
- Episode – "Half-Decent Proposal" (Mentioned)
- Episode – "Weekend at Burnsie's"
- Episode – "She Used to Be My Girl"
- Episode – "Springfield Up"
- Episode – "Take My Life, Please"
- Episode – "Moms I'd Like to Forget"
- THOH – "Treehouse of Horror XXIII"
- Video game – The Simpsons: Tapped Out