This episode marks the first of several Simpsons clip shows.
The clip of "Homer falling down the cliff" has some new animation that wasn't in "Bart the Daredevil". When Homer falls down the second time, we actually see it rather than just hearing it in the actual episode. If you look closely, you can see that the animation looks much newer.
Writers Al Jean, Mike Reiss, Jay Kogen, Wallace Wolodarsky, John Swartzwelder, Jeff Martin, George Meyer and Nell Scovell are acknowledged during the end credits of the episode.
A scene was cut but re-made into the DVD season pack where Professor Frink visits Homer's hospital room with a plan to create a shrinking submarine and plans to travel inside the Coma-ridden Homer by entering his rectum.
Barney is seen throwing a water fountain through a window. This is a reference to the movie "One Flew Over the Cuckoo's Nest".
Bart's birthday is on April Fool's Day, the family would've remember to celebrate it instead of pulling off pranks.
This part's debatable, but during one clip, the Simpsons actually remembered themselves being abducted by aliens at one point. It is unknown if the segment from Treehouse of Horror, Hungry are the Damned, is considered within continuity or not.
One repeated clip is the dream sequence from Lisa's Pony, occurring in that episode when Homer falls asleep at the wheel of his car. However, the music from the original episode - an instrumental version of Golden Slumbers by The Beatles - is replaced in the Clip Show with an unidentified piece of music, possibly intended to sound similar.
Print television ads promoted this episode as the series' finale. It was later known as an April Fools' Day joke.
There was a glitch on FXX in the airing of August 23, 2014. Two Days after the TV-PG error, The on-screen bug disappears when Bart wants to fool Homer before the day is out. Then, a few seconds later, the bug appeared when the beer worker told Bart that's it is for customers only. Many peoples said that did happen or it did not happen, but for now, It is unknown if that glitch happen.
When the veterinarian offers to spay Homer, this is incorrect since spay is the removal of the ovaries and/or uterus in a female animal. The correct medical term should have been neuter.
When Homer goes to get another beer (that had been shaken), he opens it and the house explodes. During an overhead shot of the house, you can see that one of the second floor windows has been moved further.
Call-Backs to Episodes (In order of appearance in the episode)