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Russell Brand is an English comedian, actor and presenter of television and radio. He guest starred in an Season 22 episode called Angry Dad: The Movie as himself. His ex-wife Katy Perry guest starred in the Season 22 episode The Flight Before Christmas as herself.

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Guest stars in Season 22
Kareem Abdul-JabbarHalle BerryRussell BrandCheech & ChongJemaine ClementRicky GervaisIra GlassJon HammAlyson HanniganChris HansenStephen HawkingWerner HerzogJonah HillBill JamesHugh LaurieJoe MantegnaBret McKenzieLea MicheleCory MonteithDanica PatrickKaty PerryDaniel RadcliffeAmber RileyPaul RuddMike SciosciaRachel WeiszKristen WiigMartha StewartMuhammad YunusMark Zuckerberg