This article is about the guest star. For the character, see Peyton Manning (character).

Peyton Manning is the quarterback for the Denver Broncos, the older brother of Eli Manning, and the younger brother of Cooper Manning. He appears with his brothers in "O Brother, Where Bart Thou?" Peyton won Super Bowl XLI as a member of the Indianapolis Colts, who released him after the 2011 NFL season ended.

Guest stars in Season 21

Mitch AlbomAngela BassettWren T. BrownNeve CampbellKim CattrallSacha Baron CohenBob CostasSimon CowellEllen DeGeneresKara DioGuardiAnne HathawayJonah HillEddie IzzardRandy JacksonEartha KittGary LarsonChuck LiddellCooper ManningEli ManningPeyton ManningChris MartinJackie MasonJordan NagaiYael NaimSeth RogenRyan SeacrestSarah SilvermanSmothers Brothers