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Marge is making a cake for a block party when she has an accident. She ends up having to run to the store (in disguise) to get a store bought cake.
At the block party, Marge meets Booth Wilkes-John, a British man, who invites Marge over to adult game night with his wife. Even though Marge wants to go, she thinks back to when Homer ruined another adult game night for her. Marge declines, at first, but later talks to Homer in bed about not having any friends, so she wants to go to this game night, yet Lisa chimes in with being okay with not having friends herself. Before game night, Marge reminds Homer of the proper etiquette.
At Booth's home, Marge and Homer mingle with the guests. The game begins with role play, and Homer unknowingly reveals the murderer in the story prompting Booth to kick Homer and Marge out. Marge feels depressed over not having friends, but she's set on not having Lisa go through life without friends. Marge decides to have a party for Lisa and invite everyone who knows her. The only problem is that only one boy shows up. Marge decides to scrap the idea, but the kid won't leave unless he gets a party. Marge and Homer throw the party for the kid and send him off with party favors just in time as Lisa arrives home. At Springfield Elementary, Marge goes on a mission to figure out why Lisa does not have any friends. Miss Hoover spells it out very clearly to Marge that no one in Lisa's class likes her for being to isolated and insistent in getting everyone to accept her views. Marge refuses to accept that and tries to find someone who does. When the class has to practice square dancing, Lisa is left without a partner until outside student named Tumi steps in.
It is soon discovered that Lisa and Tumi share the same interests. However, Bart quickly becomes suspicious and believes Lisa is being duped. When he follows Tumi to Krusty Burger play area, he learns the truth when he witnesses someone handing over some cash to Tumi and takes photos of the whole exchange. Bart delivers the photographic evidence to Lisa, who finds out that Tumi was being paid by Marge to be Lisa's friend and she confronts Marge for her behavior. Marge tries to apologize, but Lisa refuses to forgive her.
Soon, Abe reveals that he paid Lenny and Carl to befriend Homer in the sandbox and to this day they are still friends, much to Homer's (at first) dismay. Later, Marge has a heart-to-heart conversation with Lisa, but she still refuses to forgive Marge and intends to tell every psychiatrist about her evil deeds. Marge is in tears, which makes Lisa secretly proud and plan to use her newfound tactic to get what she wants in the future. Eventually, the thought of her mother in tears makes Lisa apologize and forgive Marge.
The next day, Tumi apologizes to her for her behavior and why she accepted the bribe from Marge for payment on a new belt. She also admits she does like being friends with Lisa. Lisa forgives Tumi, but asks for her to be more honest with her from now on. However, Lisa ditches her after she likes horse meat.