"One Fish, Two Fish, Blowfish, Blue Fish" is the eleventh episode of Season 2. The episode contains cultural references to songs such as "Theme from Shaft", "Gypsies, Tramps and Thieves", and "When the Saints Go Marching In."
Lisa convinces the family to try a new Sushi restaurant, The Happy Sumo. An error by an apprentice chef leads to Homer eating a poisonous blowfish. Dr. Hibbert gives Homer twenty-four hours to live and he sets about placing his affairs in order.
Homer takes the family to a new sushi bar, The Happy Sumo. After sampling most of the items on the menu, he tries sushi made from the fugu. The waiter tries to give Homer a minor warning but is shooed to the kitchen before he can finish. Realizing that the fish could possibly poison and kill Homer if not cut properly, one of the apprentices goes to fetch the master chef. Unfortunately, he is busy having sex with Edna Krabappel, and yells at the apprentice to leave him alone, so his apprentice has to slice the fugu. The apprentice tries to do it carefully, but Homer starts yelling impatiently, and disturbing the apprentice and forcing him to serve it. Homer considers it a treat, but the master chef soon returns and finds that the fish has not been prepared correctly and tells Homer that he may have been poisoned. Homer and Marge go to the hospital, where Dr. Hibbert informs Homer he is indeed very likely to succumb and if so has twenty-four hours left to live. At night with Marge by his side, Homer plans not to tell his kids about the bad news and makes a list of all the activities he wants to do before he passes away.
On his last day, after oversleeping, Homer attempts to do all the projects on his list. He has a man-to-man talk with Bart, listens to Lisa play her saxophone, and borrows Flanders's camcorder to make a video for Maggie that she can look at when she is older. Homer finally reconciles with his father, which takes up far more time than he expects and forces him to give up doing some of the tasks on his list. After trying to catch up on time he lost doing these accomplishments, Homer is arrested for speeding. He calls Barney, who is asked to pay $50 to bail him out. Leaving jail and with not much time left, he tells off Mr. Burns and has one last drink at Moe's Tavern with his friends, causing him to miss dinner with his waiting family. He then hurries home in time to say goodbye to the kids and make love to Marge.
At midnight, Homer quietly gets out of bed, visits each family member, who are all asleep, and says goodbye. Feeling glum, he goes to the living room and listens to Larry King read the Bible on tape. The tape plays out to which suddenly his head drops and it appears he has succumbed to the poison. Marge awakens the next morning and is panicked that her husband is not by her side. She runs downstairs and finds Homer, collapsed in the armchair. As she mourns, she realizes that his drool is still warm. She wakes him up and drums in the fact that he is alive. Homer then prances around in an overjoyed state and vows to live life to its fullest. In typical Homer fashion, he is soon back on the couch watching a bowling tournament and eating pork rinds during the credits.