Mrs. Samson is the mother of Gerald Samson, Maggie's arch nemesis. She debuted in "Lady Bouvier's Lover", but only her arms are shown. Like her son, she has a wide black unibrow as well, but not much is known about her. She is also a member of Midday Mommies mother parents meeting group. Mrs. Samson has a very different appearance in the Bart Simpson comic story, "The Maggie & Moe Mysteries!"
- Episode – "Last Tap Dance in Springfield"
- Episode – "Moe Baby Blues" (Cameo at Maggie's birthday party)
- Episode – "Pranks and Greens"
- Episode – "Halloween of Horror" (Simpson's house)
- Comic book – The Maggie & Moe Mysteries!