Mrs. Scratchy was the wife of Scratchy in the episode Loan-a Lisa during The Itchy & Scratchy Show episode P.U., a parody of the Disney Pixar movie Up. Scratchy and Mrs. Scratchy get married, buy a new home and redecorate it before growing old, mirroring the events of the main character and his wife in the movie. They relax under a tree before Itchy arrives with a machine gun and kills the couple. Itchy them buries them side by side before blowing up their graves. Itchy then proceeds to vacuum their ghosts before setting fire to the vacuum bag with a match.

A similar character that acted as Scratchy's bride was intended to get married to Scratchy in an earlier cartoon: I'm getting buried in the morning, but she as well as her fiancee ended up both being decapitated by Itchy, who was acting as the reverend, and placed their decapitated heads on strings attached to the boot of the wedding car.