The Mayo Clinic is a clinic that appeared in "The Mansion Family"; the Mayo Clinic has several locations across the United States, with the Rochester, Minnesota, location mentioned (and featured) in the episode. After Mr. Burns realizes he is the oldest living person in Springfield, Smithers took Mr. Burns to get a check-up at the Mayo Clinic, and a doctor works there. The doctor tells Mr. Burns he has "everything," including diseases newly discovered inside Mr. Burns's body, but many of these diseases cancel each other out, indicating that Mr. Burns is indestructable.
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