Bart, Milhouse and Homer get in line at Jeffery Albertson's store to purchase the first issue of a Radioactive Man reboot comic. Albertson finds out that his competitor Milo (the owner of Coolsville) is now married to his girlfriend, Strawberry. Albertson cries and sings a song about him being lonely in his entire life. Suddenly, an imaginary Stan Lee appears to Albertson and tells him that he has another chance in love. A Japanese girl named Kumiko Nakamura enters the store, Stan Lee advises Albertson not to waste the opportunity. Kumiko is in the US to research about the country's saddest cities for her autobiographical manga. Albertson asks her out for a date, and then asks Homer for dating advice, since Homer is the only fat man in real life who is married to a hot woman. During the date, Marge advises Albertson to not to be himself, however Kumiko actually likes Albertson's real personality.
Albertson continues to date Kumiko, and they plan to move in together. While dropping off a gift for Kumiko and Albertson, Homer meets Kumiko's father in front of the store. Homer tells the gentleman about Albertson being an obese nerd, which prompts Mr. Nakamura to object their relationship and take Kumiko away. Marge tells Homer to make plans, so Homer takes Mr. Nakamura to a Japanese bar. They both drink Habushu (Snake Rice Wine), an incredibly strong form of rice wine (and Homer drinks what he thinks was fish wine when actually it was the restaurant aquarium) and stumble home intoxicated, where the city turns into a wonderland based on Studio Ghibli's films (specifically Spirited Away, My Neighbor Totoro, Ponyo, Princess Mononoke, Howl's Moving Castle, Kiki's Delivery Service, and Porco Rosso). Mr. Nakamura learns that by forbidding the relationship, he is taking away Kumiko's life.
Albertson tries to impress Mr. Nakamura by getting a real job using his hitherto unmentioned chemical engineering degree. Mr. Nakamura tells him that he does not have to get a real job since he already likes Albertson the way he is. The episode finishes with Albertson and Kumiko getting married by Stan Lee in the Comic Book Store.