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Mark Zuckerberg is the founder of the popular social networking site Facebook. After founding the site while in college, he has a 24% share in the site and, as such, is now a billionaire, becoming such while still in his mid-20s.

He plays himself in the episode "Loan-a Lisa". His role in that episode was to reveal to Lisa and Nelson about how many achievers actually dropped out of school.

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Guest stars in Season 22
Kareem Abdul-JabbarHalle BerryRussell BrandCheech & ChongJemaine ClementRicky GervaisIra GlassJon HammAlyson HanniganChris HansenStephen HawkingWerner HerzogJonah HillBill JamesHugh LaurieJoe MantegnaBret McKenzieLea MicheleCory MonteithDanica PatrickKaty PerryDaniel RadcliffeAmber RileyPaul RuddMike SciosciaRachel WeiszKristen WiigMartha StewartMuhammad YunusMark Zuckerberg