The very first Itchy cartoon is parodying Oswald the Lucky Rabbit. The plot revolves Itchy (looking noticeably different due to this cartoon being drawn by Itchy's original creator Chester Lampwick) strutting around Manhattan while he decides to hurt people throughout the day. The victims include an Irish person (who was wrung through an old washing machine starting with his beard) and President Theodore Roosevelt (who was decapitated with an axe). Itchy, now bloodied, winks at the screen and the cartoon ends.
Despite being made in 1919, the Empire State Building (1931) can be seen in the skyline in the beginning.