- “Oh, for Pete's sake”
- ―Lois' reaction to Peter's comic in The Simpsons Guy
Lois Patrice Griffin (née Pewterschmidt) is Peter Griffin's wife, the mother of Meg, Chris and Stewie Griffin and the owner of a talking dog, Brian Griffin. She is best friends with her neighbor, Bonnie Swanson. She is of the main characters from American animated sitcom Family Guy. She appears in the episode Homerland and a crossover special, The Simpsons Guy.