- Sleeping with the Enemy
- Sleeping with the Enemy/Appearances
- Sleeping with the Enemy/Credits
- Sleeping with the Enemy/Gags
- Sleeping with the Enemy/Gallery
- Sleeping with the Enemy/Quotes
- Sleeping with the Enemy/References
- Sleepless in Seattle
- Sleepless in Springfield
- Sleepless in Springfield/Appearances
- Sleepless in Springfield/Credits
- Sleepless in Springfield/Gallery
- Sleepless in Springfield/Quotes
- Sleepless in Springfield/References
- Sleigh Ride
- Slender Vittles
- Slenderman
- Sleve McDichael
- Sliced Family couch gag
- Slide Factory
- Slightly Creepy Boy
- Slim Mints
- Slimu
- Slinky Dog
- Slippery Mountain Goat
- Slipreme
- Slithers
- Sloan
- Slobodan Milošević
- Slot Car Heaven
- Slot Machine couch gag
- Slovakia
- Slow Leonard
- Small Chair couch gag
- Small Strike Zone
- Smarch
- Smart Boy
- Smart Boy 2
- Smart Elf
- Smart Girl Six Three
- Smart Tykes
- Smart and Smarter
- Smart and Smarter/Appearances
- Smart and Smarter/Credits
- Smart and Smarter/Gags
- Smart and Smarter/Gallery
- Smart and Smarter/Quotes
- Smart and Smarter/References
- Smartline
- Smartphones couch gag
- Smash Diggins
- Smash the Flag
- Smeared couch gag
- Smell Your Breath
- Smiley
- Smilin' Joe Fission
- Smithers's future girlfriend
- Smithers Family
- Smitherses!
- Smitherses!/Appearances
- Smitherses!/Credits
- Smitherses!/Gallery
- Smitherses!/Quotes
- Smitherses!/References
- Smithsonian Guard 1
- Smithsonian Guard 2
- Smithsonian Museum Robbery couch gag
- Smitty
- Smoke Factory
- Smoke on the Daughter
- Smoke on the Daughter/Appearances
- Smoke on the Daughter/Credits
- Smoke on the Daughter/Gags
- Smoke on the Daughter/Gallery
- Smoke on the Daughter/Quotes
- Smoke on the Daughter/References
- Smoke on the Water
- Smoker
- Smokey the Bear
- Smooches On The Beach
- Smooshies
- Smothers Brothers
- Smug Girl
- Snack Clerk
- Snack Delivery Man
- Snack Shack
- Snacks
- Snake's Kin
- Snake's Kin/Appearances
- Snake's Kin/Credits
- Snake's Kin/Gallery
- Snake's Kin/Quotes
- Snake's Kin/References
- Snake's Relative
- Snake's ex-wife
- Snake Jailbird
- Snake Jailbird/Gallery
- Snake Jailbird (The Serfsons)
- Snake Rice Wine
- Snapple
- Sneakers
- Sneaking in at Noon
- Sneed
- Sneed's Feed & Seed
- Snoop Dogg
- Snooze
- Snooze at 11
- Snot Wheels
- Snow Brawl
- Snow Brawl/Appearances
- Snow Brawl/Credits
- Snow Brawl/Gallery
- Snow Brawl/Quotes
- Snow Brawl/References
- Snow Falling on Cheaters
- Snow Globe couch gag
- Snow Mom
- Snow Monster
- Snow White
- Snowball I
- Snowball II
- Snowball II's kittens
- Snowball III
- Snowball II Municipal Cat Park
- Snowball Simpson (disambiguation)
- Snowball V
- Snowshoe Casino
- Snuffles
- Snuffy
- Snuggler's Cove
- So Dumb (Homer's Lament)
- So It's Come to This: A Simpsons Clip Show
- So It's Come to This: A Simpsons Clip Show/Appearances
- So It's Come to This: A Simpsons Clip Show/Credits
- So It's Come to This: A Simpsons Clip Show/Gags
- So It's Come to This: A Simpsons Clip Show/Gallery
- So It's Come to This: A Simpsons Clip Show/Quotes
- So It's Come to This: A Simpsons Clip Show/References
- So Long, Chum!
- So Long, Chum!/Appearances
- So Long, Chum!/Credits
- So Long, Chum!/Gallery
- So Long, Chum!/Quotes
- So Long, Chum!/References
- So You're Calling God a Liar!
- So You've Decided To Steal Cable
- So You've Got a Restraining Order
- So You've Ruined Your Life
- Soccer Mummy
- Soccer couch gag
- Social Security Office
- Society of American Baseball Research
- Society of Structural Engineers
- Socks Stillman
- Socrates
- Sofa So Good
- Sofa So Good/Appearances
- Sofa So Good/Credits
- Sofa So Good/Gallery
- Sofa So Good/Quotes
- Sofa So Good/References
- Sofia Vergara
- Solar Energy
- Solar Panel
- Sold Separately
- Soldier
- Soldier 1
- Soldier 2
- Solicitor Mob
- Solomon
- Solomon Islands
- Solvang
- Solvang Air
- Somalia
- Some Enchanted Evening
- Some Enchanted Evening/Appearances
- Some Enchanted Evening/Credits
- Some Enchanted Evening/Gags
- Some Enchanted Evening/Gallery
- Some Enchanted Evening/Quotes
- Some Enchanted Evening/References
- Some Enchanted Evening/Transcript
- Some Tramp He Met In St. Louis
- Someday
- Someone's in the Kitchen with DNA!
- Someone to Watch Over Me
- Somethin' Stupid
- Sometimes When We Touch
- Son (The Wizard of Evergreen Terrace)
- Son (There's No Disgrace Like Home)
- Song of Shelbyville
- Song of the Wild Beasts
- Songs in the Key of Springfield
- Songs to Enrage Bus Drivers!
- Sonic Youth
- Sonic Youth (characters)
- Sonic the Hedgehog
- Sony Pictures Studio
- Sony Pictures Studios
- Sonya
- Sop Sign
- Sophie Jensen
- Sophie Krustofsky
- Sophie Krustofsky/Gallery
- Sorghum Farmer
- Sorry Not Sorry
- Sorry Not Sorry/Appearances
- Sorry Not Sorry/Credits
- Sorry Not Sorry/Gags
- Sorry Not Sorry/Gallery
- Sorry Not Sorry/Quotes
- Sorry Not Sorry/References
- Sound Thinking!
- Sound Thinking!/Appearances
- Sound Thinking!/Credits
- Sound Thinking!/Gallery
- Sound Thinking!/Quotes
- Sound Thinking!/References
- South Africa
- South African band
- South Dakota
- South Korea
- South O' the Equator Gift Shoppe
- South Park
- South Pole Research Station
- South Street Squidport
- South of the Border
- Southern Cracker
- Southern Fried Simpsons
- Southern Fried Simpsons/Appearances
- Southern Fried Simpsons/Credits
- Southern Fried Simpsons/Gallery
- Southern Fried Simpsons/Quotes
- Southern Fried Simpsons/References
- Southern Sheriff
- Southpaw Superstore
- Sox
- Soy Pop
- Soy Rogers
- Soylent Green
- Space Marshmallow
- Space Mutant Female Victim
- Space Mutant Male Victim
- Space Mutants
- Space Patrol
- Space Patrol/Appearances
- Space Patrol/Credits
- Space Patrol/Gags
- Space Patrol/Gallery
- Space Patrol/Quotes
- Space Patrol/References
- Spain
- Spain (Rio Parody)
- Spanish Eyes
- Spanish Flea
- Spanish Squeaky-Voiced Teen
- Sparkle
- Sparklemon
- Spay Anything
- Special Delivery
- Special Delivery/Appearances
- Special Delivery/Credits
- Special Delivery/Gallery
- Special Delivery/Quotes
- Special Delivery/References
- Special Edna
- Special Edna/Appearances
- Special Edna/Credits
- Special Edna/Gags
- Special Edna/Gallery
- Special Edna/Quotes
- Special Edna/References
- Special Girl
- Special K
- Specs and the City
- Specs and the City/Appearances
- Specs and the City/Credits
- Specs and the City/Gags
- Specs and the City/Gallery
- Specs and the City/Quotes
- Specs and the City/References
- Speed-E-Mart
- Speed-E-Mart owner
- Spelling
- Spellympic Village
- Spellympics
- Sperm Bank Clerk
- Sperm Bank Employee
- Spherical on 34th Street
- Spider-Man
- Spider-Pig (song)
- Spider Cordon Bleu
- Spider Monster
- Spiffany's
- Spiffy
- Spike Feresten
- Spike Lee
- Spin-offs
- Spinal Tap
- Spinal Tap Bus
- Spinal Tap Effects Artist
- Spinal Tap Stagehand
- Spine Melter 2000
- Spinning Newspaper couch gag
- Spinster City Apartments
- Spirit Guide
- Spirograph Factory
- Spiro’s
- Spittle County
- Splatterface
- Split Decisions
- Split Decisions/Appearances
- Split Decisions/Credits
- Split Decisions/Gallery
- Split Decisions/Quotes
- Split Decisions/References
- Splitsville Icecream Sundaes
- Spoiler Boy
- SpongeBob SquarePants
- Sponge and Vacuum
- Sponsor Bunny
- Spoonbill
- Sportacus
- Sportacus clerk
- Sports Car (The Simpsons: Hit and Run)
- Sports Spew! With Roy Firestone
- Sportscaster 1
- Sportscaster 2
- Sportscaster 3
- Spot the Hidden Objects
- Spot the Hidden Objects: Volume 1
- Spot the Hidden Objects: Volume 2
- Spotlight couch gag
- Sprank Flanders
- Sprawl-Mart
- Spray Booth Man
- Spray Paint couch gag
- Spree For All
- Spree For All/Appearances
- Spree For All/Credits
- Spree For All/Gallery
- Spree For All/Quotes
- Spree For All/References
- SpringFace
- SpringShield
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