"Little Big Mom" is the tenth episode of Season 11. It first aired on January 9, 2000, meaning it was the first episode to be aired in the 3rd millennium. The episode was written by Carolyn Omine and directed by Mark Kirkland. Elwood Edwards guest stars as the Virtual Doctor.
When Marge cleans out the attic, looking for items to give away or sell, Homer and the kids refuse to let her do it. This prompts Marge to look at all the junk she is trying to get rid of, including old game boxes (minus the games) and other useless or broken things the family never use but won't part with. She shows Homer several skis he never used since buying them after the Nagano Olympics. To spite Marge, he says he is going to use them, which makes the family go on a skiing trip. When they are there, Marge decides that she wants to avoid skiing or snowboarding, for fear of injury. While staying in the ski lodge, however, a loose-hanging clock falls and breaks Marge's right leg. She goes to the hospital, and Dr. Hibbert declares that she must stay there until her cast is removed.
In the meantime, Lisa offers to take her place, making a structured plan for Homer and Bart to do the chores, which Lisa chooses through a chore hat. Unfortunately, Homer and Bart refuse to do any chores, and when Lisa finally prods them into doing some work, they do so in an extremely apathetic and ineffective manner, such as leaving dishes in the sink for days on end. Marge is enjoying her time in the hospital, due to getting a massage, among other things. The lazy lifestyles of Homer and Bart have taken their toll on the house, which is now a disorganized, filthy hovel with trash everywhere, with Lisa struggling to make ends meet. She even calls Marge and asks if she can return - Marge, who enjoys the lifestyle of lying all day in bed not working, lies to Lisa saying she is still too ill to come back. Lisa, angered, abandoned and desperate for answers, meets the ghost of Lucille Ball, who has an idea to get revenge. She suggests that she pull a clever trick on Homer and Bart while they are asleep. Indeed she does, and using green poster paint and oatmeal on the men, she tricks them into thinking that they have leprosy.
The next morning, Homer and Bart are told by Lisa they have leprosy from living in dirty conditions, therefore they need to clean up the house. Homer and Bart consider this supposed cure worse than the disease, so go see the Flanders family instead, thinking Ned can give them a quick and easy cure. Ned is terrified, and sends the two of them to a leper colony in Hawaii, where they will be needled and sanded.
Once Marge's cast has finally come off (and her excess leg hair has been waxed), she comes home to see an angry Lisa finally done with cleaning the entire house. They decide to seek out Homer and Bart in Hawaii. When they arrive, Lisa admits that she only played a trick on Homer and Bart (Homer already knows the leprosy is fake because he ate one of the sores); however, they want to stay there on account of it being a "free vacation" (all for just two hours of blinding pain a day).