| Isabel Gutierrez|
|Occupation||Student at Springfield Elementary School|
|First Appearance||"The Kid is All Right"|
|Voiced By||Eva Longoria|
Isabel is Lisa's new friend. Isabel herself is from Argentina and is also Jewish. She met Lisa in the school library. Things seemed to be okay until Isabel revealed to Lisa that she is a Republican, during a presentation about Franklin Roosevelt.
Bart revealed that Isabel rides a bike with training wheels. She and Lisa eventually ran against each other in the second grade election, which Isabel won the second grade election.
- She has a darker skin complexion in the episode compared to her official image.
- Episode – "The Kid is All Right" (Debut episode)
- Episode – "Yellow Subterfuge" (Name was shown on list)