Inside of the Android Dungeon comic book store, in one scene behind Bart and Comic Book Guy, a "World Champ Boston Red Sox" pennant is hung on a bookshelf. The Red Sox were just coming off of a World Series victory over the Colorado Rockies when this episode aired.
The slogan of Shapes, as seen on the wall of the workout station room, is "I am woman, hear me sweat." The slogan is a pun on the lyric "I am woman, hear me roar" from the song "I Am Woman" by Helen Reddy.
There is a real fitness chain called Shapes in Florida.
The comics displayed behind the writers at the signing are Lost Girls, Maus, and Ghost World, respectively written by guest stars Alan Moore, Art Spiegelman, and Dan Clowes. Art Spiegelman's mask is based upon the mask he has drawn himself wearing as an illustrator in Maus.
Alan Moore's outburst at Milhouse's request that he sign the comic Watchmen Babies in V for Vacation (a parody of Watchmen and V for Vendetta), is a reference to Moore's opposition to adaptations of his works by major film studios, particularly his refusal to support the recent film adaptation of V for Vendetta.
Two popular European comic books, Asterix and Tintin, are referenced. The book Tintin in Paris is a parody of the books The Black Island and Destination Moon. Also shown are several actual Tintin books, such as The Shooting Star and Tintin in Tibet.
Coolsville Comics & Toys in this episode is a parody of the real store Meltdown Comics & Collectibles on Melrose in Hollywood, California. The writers of the show go there for their comics. Coolsville looks almost like Meltdown except for slight differences.
When Comic book guy tries to lure his customers back with ninja weapons in this episode the writers are making an indirect joke at the real world Toy Mandala, a comic store competitor of Meltdown Comics & Collectibles. Toy Mandala does actually sell ninja weapons in real life and is a comic store. They do not, however, sell weapons to children.
Kearney says to Marge that she skinnier than Girthquake and Flabberella.