Homer's attempt to alert the press of the move by showing them a room of evidence, only to find nothing incriminating is found, is a likely reference to the film Moonraker, where James Bond discovers that Hugo Drax is operating a lab making deadly gas. When Bond takes M and his superiors to investigate the lab, he finds it has been replaced with a dining room.
Homer's "Dancing Away My Hunger Pangs" song was actually ad-libbed by Dan Castellaneta.
The real-life minor league baseball team Albuquerque Isotopes take their name from this episode.
"Veggie" is misspelled as "vegie".
Homer's hunger strike lasted 12 days and during that time he had no access to drinks as well as food. However, one can only survive 3 days without water.
Duffman's first name (Sid) was mentioned here, even though "Pygmoelian" established that Duffman's real name was Larry. In "Jaws Wired Shut", it's revealed that Duffman has been played by multiple actors (as each actor who has played Duffman has died, hence the line, "Duffman can never die; only the actors who play him) and "Marge and Homer Turn a Couple Play" reveals that, much like mall Santas, there are multiple Duffmen working, but it's kept a secret so as not to disillusion children.
On American TV, the original ending in which the Mayor of Albuquerque decides not to buy the Springfield Isotopes and instead buys the Dallas Cowboys was edited in reruns, making the episode end with Homer celebrating the end of his hunger strike. Overseas airings and the season 12 DVD set has the original ending uncut and uncensored.