Apu, Skinner, and Moe were all volunteer firefighters in this episode. They would later also be volunteer firefighters in "Crook and Ladder." And Apu, Moe, and Ned Flanders were also volunteer firefighters in Brother's Little Helper. Luann van Houten was shown as being a member of the Volunteer Fire Department in this episode.
Some fans of The Simpsons have held parties on June 5th and calling it "The Feast of Maximum Occupancy", in reference of Homer's excuse to get out of work by making up a holiday by looking at the safety warning at Moe's Tavern, which read "Maximum Occupancy, 65". The June 5th party date is a reference to the digits 6 and 5.
At the end of the episode, God mentions that Homer has to wait 6 months to know the meaning of life, because Homer will die. Homer later dies for a few seconds in "Homer's Triple Bypass". Ironically, that episode also has Homer dreaming about what is implied to be Hell and referring to it as a "wonderful dream."
Despite this, God soon tells Homer the meaning of life, but the closing credits start before the audience can hear it.
This is the first episode to be animated by Film Roman.
The date of the Playdude is July 1986.
This episode shows how Homer was born. Unlike Bart's birth in "I Married Marge", Lisa's birth in "Lisa's First Word", and Maggie's birth in "And Maggie Makes Three", Homer was seen being born from inside the womb and not from outside the womb. You can clearly tell this by the womb's shape at the beginning of the scene, the amniotic sac breaking after Homer's dance, the umbilical cord that's attached to Homer before he pulled it out from the womb, and a hand (possibly the surgeon's) pulling Homer's legs out of the womb while he grasps onto it as he gets delivered.
However, just before the rest of Homer gets delivered after his legs, the scene cuts to the present, where Homer, grabbing onto his bed's headboard (similar to how he grasped the womb when he was delivered), is getting pulled out of bed by Marge. This reveals that Homer was dreaming about his birth, and Marge was pulling on Homer while telling him to wake up, similar to how the surgeon's hand pulled Homer out of the womb at the end of Homer's dream about his birth.
This episode also reveals that Homer was a breech baby and he was born via a breech delivery during Homer's dream about his birth. You can clearly tell this by the surgeon's hand delivering Homer's legs first.
At the end of the episode when Homer sets the family home on fire he is rescued by Ned Flanders, however it is a Sunday, therefore Ned should have been at church. Even very religious people will skip church sometimes. Also, most churches have more than one mass so Ned could have went earlier or later. Similarly, some sects of Christianity split the church into "wards", so as to avoid overcrowding by having everyone at church at once; Ned's "ward" may have attended earlier. It's also possible that Ned was late and was on his way there when he saw the fire.
God is the only character to have 5 fingers on each hand, but only has 4 on each hand (like most Simpsons characters) during the scene at the end of the episode.
When Marge says, "Kids, your father doesn't really mean that," Bart is in front of Homer, but immediately afterward, Bart is suddenly behind Homer. Then, when Marge asks, "Homer, are you actually giving up your faith?" Bart is in front of Homer again.