Lisa married Milhouse but seems to have keep her maiden name, since her daughter's full name is Zia Simpson. Lisa's Christmas card it says a complicated "Merry Christmas from Simpson-Van Houten-Simpson-Simpsons" which may imply that Lisa kept her last name, Milhouse took on the hyphenated Simpson-Van Houten surname and Zia has her mother's last name.
Martin Prince has undergone a sex change to become Martha Princess.
Just like previous flash-forward episodes, Maggie never says anything. The robot nurse told her not to say a word for the duration of her pregnancy from that point forward. In addition, there were points when she was about to speak, but was interrupted by her own contractions and Abraham. However, she is shown to be a world famous singer, enhancing the gag through irony. Similar to Lisa's Wedding, where its revealed she is as a good singer, but gets interrupted before she can use her talent.
Lisa also questions if she should have married Nelson, indicating that they were once together. This also indicates that Nelson proposed to Lisa sometime before she married Milhouse, most likely at the same time as Milhouse had proposed.
Lisa says that her and Nelson still talk, saying that, "Someone calls someone." when Bart says, "Nelson calls you?", indicating that she calls him, and not the other way around.
Jenda from Future-Drama appears in a picture. It's revealed that she married Bart, had two children with divorced him, and married her new boyfriend in secrecy.
At some point, paper cash will no longer be in use, according to Apu.
Originally, this episode was supposed to be the series finale, as Fox was considering cancelling the show due to money issues stemming from advertising the show. Once the issues were resolved with a pay cut for all involved with the show, the series was greenlit for seasons 24 and 25.
If Zia is 13 years old and this episode is taking place in 2041, then this places Zia's birthdate somewhere around 2027 or 2028 depending on what day Zia was born.
In this episode, Homer is 69 years old, Marge is 64, Bart and Milhouse are 40, Lisa is 38, Maggie is 31, and if Abe weren't frozen in age, he would be 113 years old.
In the four years later picture, Lisa is shown to be a Goth, similar design in Smart and Smarter when she was trying to change her image.
Maggie looked exactly like Lisa growing up in the opening.
There is a future episode every 5 years- except the one before 'Holidays of Future Passes' was 6 years previous. This is because this episode was originally written to be the series finale in season 23, but the show got renewed so they made this one of the future episodes, just a year late.
In the description of the Sky 1 airing of the episode, there is a mistake saying it is the fifth episode of Season 23, not the ninth.
There are only 42 octuplets of the octuplets. If all of the octuplets had octuplets, there should be 64. This is either a goof or not all of them are there.
Grandpa's hat is slightly lower in the reflection of himself.
Carl (with Lenny's brain) tells Lenny (with Carl's brain) to stop making Lenny fat, but in Sweets and Sour Marge, Lenny is one of the people in the sugar, and even looses some of his teeth.
When Lisa enters the Ultranet she comments that it is Dr Seuss' birthday as indicated by the design of the Google page. Dr Seuss' birthday is March 2 and this episode takes place over Christmas.
When Lisa first goes into the Ultranet there are two of the same people in one scene.
Despite Edna being killed by Homer, she appears at Lisa's Ultranet friend requests. However, it could be possible she sent the request before she died. This gives off the impression that Lisa isn't a very frequent Ultranet user.
Zia's drool is missing when we see her and her mother are in the table while both are on the Ultranet.
Lisa and Homer refer to Prince Harry as one of history's tyrants, strongly implying that he eventually became King, though they still refer to him as a Prince rather than King.
The family is grown up in this episode but remain the same voices.