Fifi Bouvier is the daughter of Antoine Bouvier and Françoise Billout. Her siblings were Pépé Bouvier, Monique Bouvier, Lalique Bouvier and Coquette Bouvier. Bambi Petitbois is her sister-in-law and Maurice L'eau is her brother-in-law.
Her nephews are Clancy Bouvier, JoJo Bouvier, Chester Bouvier, Theodore L'eau and Hi L'eau. Her nieces are Charlene Bouvier and Tilda L'eau, and her nieces-in-law are Jacqueline Bouvier and Alfreda LeDoux.
Her grandnieces are Marge Simpson, Patty Bouvier, Selma Bouvier, Dorothé Bouvier, Tootsie Bouvier, Rowena Bouvier and Alfreda Bouvier II. Her grandnephew-in-law is Homer Simpson. Her great-grandnephews are Bart Simpson and Axel Bouvier, and her great-grandnieces are Lisa Simpson, Maggie Simpson, Ling Bouvier (adopted), Dolly Bouvier, Lolly Bouvier, Polly Bouvier and Holly Bouvier.