Upon learning that Maya finds him attractive, Moe joyfully utters the nonsense phrase, "Oh, frabjulous day, calloo callay!" which is a reference to a similar line in the Lewis Carroll poem "Jabberwocky."
When Moe sees Dr. Nick to have size-change surgery, Nick is about to give him the anesthetic and tells him that when he wakes up, he'll be a woman. Moe, taken aback, sits up and says that's not what he came in for. At this, Nick apologizes and says he must have gotten his files mixed up. An indignant and newly short Mr. Largo then appears in the doorway, complaining to Dr. Nick—implying that Largo was the one wanting a sex-change operation.
Crazy Cat Lady is shown to be lucid enough to talk (or even use a computer).
This is the second episode where Homer brings Maggie to Moe's Tavern. The first was Bart Sells His Soul.