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Dr. Octopus is a supervillain to Spider-Man.
While walking at the Springfield Cemetery, Lisa saw Nick Riviera who was robbing graves. When he noticed her, he pretended to be Dr. Octopus using arms he acquired. Then he told her that she had a check-up on Tuesday and Lisa replied with "we go to a better doctor". Dr. Nick then walked away.
- Episode – "The Girl Who Slept Too Little" (Mentioned)
- Episode – "The Haw-Hawed Couple"
- Episode – "Stealing First Base" (Mentioned)