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Chicks with Cliques is a guidebook for girls on how to become popular.
When Homer noticed that Lisa is alone at school, he found this book in the "What's wrong with my daughter" section of the bookstore. Lisa wasn't sure about the book at first, so Homer demonstrated it with his friends at Moe's Tavern. However, Lisa didn't change her mind. Homer then told her that she isn't ready for the book, because it's more of a big girl thing. Lisa replied that she is a big girl and eventually took the book and tested some tricks on Lenny and Carl.