Charles may refer to:
- Charles Montgomery Burns, the richest man in Springfield
- Charles Heathbar, Marge's husband in the reality show from "Homer Simpson, This Is Your Wife".
- Charlie (SNPP), Homer's co-worker at the Springfield Nuclear Power Plant
- Charlie (orphan), Bart's adopted brother in "O Brother, Where Bart Thou?"
- Prince Charles, Queen Elizabeth II's son
- Charles Napier, occasional Simpsons guest star