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Charlene Marie Bouvier is or was the only daughter of Pépé Bouvier/Meaux and Bambi Petitbois/Genevieve Bouvier and the sister of Clancy Bouvier, the paternal aunt of Patty, Selma and Marge Bouvier. She is also the sister-in-law of Jacqueline Bouvier, the aunt-in-law of Homer Simpson on his father-in-law's side, and the maternal grandaunt of Bart Simpson, Lisa Simpson, Maggie Simpson on their maternal grandfather's side, and the adoptive maternal grandaunt of Ling Bouvier. Like most Bouvier women, Charlene was a heavy smoker.

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