This category has characters who have frequently appeared in the show.
All items (1246)
S
- Sherri and Terri's Great-Aunt
- Sadruddin Mahbaradad
- Sailor Kid
- Richie Sakai
- Sakatumi
- Sam (barfly)
- Gerald Samson
- Colonel Sanders
- Sandwich Delivery Guy
- Santa's Little Helper
- Sara (Student)
- Sardonicus
- Sauna User 1 (couch gag)
- Sauna User 2 (couch gag)
- Sauna User 3 (couch gag)
- Scarlet Tanager
- Scary Vultures
- Gunter
- Arnold Schwarzenegger
- Mike Scioscia (character)
- Scorpio Family
- Hank Scorpio
- Scratchy
- Scratchy Jr.
- Sebastian Cobb
- Security Male with Brown Haired
- Selma's Exes
- Senator Mendoza
- Sequelizer
-
- The Seven Duffs
- Señor Ding Dong
- Señora Bumblebee Man
- Joey Jo-Jo Junior Shabadoo
- William Shakespeare
- Cecile Shapiro
- Sharks (couch gag)
- Jay Sherman
- Sherri and Terri
- Sherri and Terri's sister
-
- Sherri Mackleberry
- B.F. Sherwood
- Shotgun Pete
- Dave Shutton
- Sid (Duffman)
- Sideshow Raheem
- Al Simmons
- Beatrice Simmons
- Mindy Simmons
- Simpson fish
- Abbey
- Abe Simpson II
- Abraham Simpson I
- Amber Simpson
- Chet Simpson
- Dr. Simpson
- Aunt Hortense
- Hugo Simpson II
- Lisa Simpson
- Maggie Simpson
- Marge Simpson
- Mona Simpson
- Orville Simpson
- Stanley Simpson
- Frank Sinatra
- Llewellyn Sinclair
- Singapore
- Sirloin Staff
- Skinner family
- Agnes Skinner
- Seymour Skinner
- Seymour Skinner (real)
- Sheldon Skinner
- Skippy Simpson
- Sara Sloane
- L.T. Smash
- Waylon Smithers, Jr.
- Waylon Smithers, Sr.
- Smitty
- Smug Girl
- Snow Monster
- Snowball I
- Snowball II
- Snowball III
- Snowball V
- Roy Snyder
- Sonic the Hedgehog
- Sophie Jensen
- Space Mutants
- Mr. Sparkle (mascot)
- Spider-Man
- Spike Lee
- Spirit Guide
- Springfield Atoms
- Springfield bears
-
- Springfield Mafia
- Jebediah Springfield
- Miss Springfield
- Spuckler Children
-
- Birthday Spuckler
- Brandine Spuckler
- Cletus Spuckler
- Gummy Sue Spuckler
- International Harvester Spuckler
- Jitney Spuckler
- Mary Spuckler
- Maw Spuckler
- Q-Bert Spuckler
- Rubella Scabies Spuckler
- Taylor Spuckler
- SpongeBob SquarePants
- Squawky
- Frankie the Squealer
- Stacy Lovell
- Stampy
- Samantha Stankey
- Dolph Starbeam
- Stewie Griffin
- Sting (character)
- Stonecutters
- Strawberry
- Strongman Homer
- Stu Discothèque
- Stuart
- Stuart (All's Fair in Oven War)
- Stupid Sexy Flanders
- Summer Romance girl
- Supporting Man
- Surly Duff
- Surly Joe
- Susan
- Lucius Sweet
- Szyslak Family
- Minnie Szyslak
- Moe Szyslak