The main character of American Dad!: a CIA agent and staunch . Stan is Francine's husband and Hayley and Steve's father. He is voiced by Seth Macfarlane.
Stan's wife and mother of Steve and Hayley. Francine is an enabler, usually going along with the actions of the family, though she occasionally serves as the voice of reason. Despite her ditzy personality, she demonstrates a keen wild streak and a flirty nature. She is voiced by Wendy Schaal.
Stan and Francine's daughter. She is eighteen and attends a college. She is portrayed as ultra-liberal, which often brings her into conflict with her father. She is voiced by Rachel MacFarlane.
Stan and Francine's fourteen-year-old son. He is a geek, which Stan does not like. He has also come into conflict with Stan, who wants Steve to follow in his footsteps. He is voiced by Scott Grimes.
Roger is an alien who lives in the Smith family's attic. Stan feels he "owes Roger his life" after being saved by the alien at Area 51 four years prior to the show beginning. Roger is a hedonistic alcoholic who takes on make believe personas and makes the Smith family's life extremely difficult with his vices, but since exposing Roger as an alien would endanger Stan and the rest of the family, those personas are Roger's only way of communicating with the outside world. He also has a strong addiction to junk food and can also hold long-standing grudges. He is voiced by Seth MacFarlane.
Klaus was once an East German Olympic ski-jumper until his mind was transferred into the body of a goldfish during the 1986 Winter Olympics by the CIA to prevent him from winning the gold medal, leaving him permanently trapped in the goldfish's body. Despite this, Klaus still hasn't come to terms with what happened and is very bitter. He stays in a fishbowl in the Smiths's home and has something of an obsessive crush on Francine. He is voiced by Bradley Dee Baker.
Jeff Fischer is introduced as Hayley's loser, stoner, hippie boyfriend. He is an unemployed high school drop out, and is frequently naive or stupid, irritating other characters. His mother abandoned him early on, giving birth to him in his van, within which he lives until Season 6. His relationship with his father Henry is poor, as his father also views him as a failure. Throughout the series, Hayley repeatedly dumps him for being needy, clingy and overly agreeable, leaving Jeff crushed until their inevitable reconciliations, though Jeff also dumps Hayley once in the episode Pulling Double Booty". However, he marries Hayley in the show's 100one-hundredth episode after swindling Stan out of $50,000. He then moves into the house with Hayley in the episode "There Will Be Bad Blood". In "For Whom the Sleigh Bell Tolls", Stan ends up accepting Jeff when Jeff demonstrates his loyalty toward Hayley by saving Stan's life despite disliking him. Jeff is based on Seth MacFarlane's friend of the same name, who also voices him.
American Dad! references in The Simpsons
|In The Italian Bob, Stan appears in the criminal book, guilty of plagiarism of plagiarism (Suggesting American Dad copied Family Guy, which had already copied The Simpsons).|
|In the ending credits of Homerland, the cast of American Dad!, along with characters from other FOX cartoons, such as Family Guy, The Cleveland Show, and Bob's Burgers, all go to a 25th season premiere of The Simpsons.|
|In The Simpsons Guy, Roger appears when Kang and Kodos were pleased with Homer and Peter's fight, Roger comes in and also announces he is also pleased. Roger breaks the fourth wall and tells the audience that he went to Summer camp with them. The ship then gets destroyed and the three aliens are sucked out of the ship in a space vacuum. As he leaves, Roger continues to break the fourth wall as he thanks the creators for having him visit the crossover episode.|
The Simpsons references in American Dad!
|In 100 A.D., Roger announced what the special episode was going to be about. He said that in this episode, they'll be finding out Who Shot Mr. Burns?, only to find out that the special event he's actually talking about happened 15 years ago and learns that Maggie is the one who shot him.|
|In Faking Bad, Steve starts a business, selling fake IDs to people. He calls out the names on the fake IDs as he gives them out. One of them he reads is "Mike Rotch". Bart Simpson then appears, laughing revealing himself to have bought that ID, and chosen that name specifically to get Steve to sound like he was saying "My crotch" in a similar fashion to how he makes his infamous prank calls to Moe.|
|Jeff and the ghost of Sinbad were travelling through a wormhole and they were transforming into a bunch of different versions of themselves. One of them was a Simpsonized version of themselves.|