An image of Itchy from Itchy & Scratchy can be seen during Cletus' story.
The episode does not actually feature twenty-two stories, but according to the DVD commentary, the title was decided from the start, regardless of how many stories would actually end up in the episode.
This episode reveals that Dr. Nick drives with corpses to get through carpool lanes. In The Fat and the Furriest, Homer disguised his candy ball as a passenger to drive through a carpool lane.
This episode was supposed to be the pilot episode for a spinoff series that focused on the lives of everyone in Springfield except the Simpsons. That would have been too much work and the idea was abandoned.
Like Quentin Tarantino's film, Pulp Fiction,the episode's plot is episodic and interconnected. Additionally there are several more lengthy parodies. The ensemble of the Chief Wiggum, Snake and Herman plot is based on the "Gold Watch" segment of the film. Wiggum, Lou and Eddie's conversation about McDonald's parallels the famous "Royale With Cheese" discussion between Vince Vega and Jules Winnfield. Later, Snake runs down Wiggum like Butch Coolidge does to Marsellus Wallace. He then crashes into a wall, running down a fire hydrant and mailbox just like in the film. The two then fight and roll into Herman's shop, he ties them up, ballgags them and waits for Zed to arrive before being knocked out by a medieval weapon yielded by Milhouse. This again mirrors the film, with Herman in the role of Maynard.
1999: Apu's line "I'm going to party like it was on sale for $19.99!" references Prince's song.
E.R.: Dr. Nick's scenes parody the popular medical series.
Bazooka Joe: When people are giving suggestions to Lisa, Lionel Hutz suggests that Lisa keep the gum in as evidence, as Bazooka Joe has deep pockets.
Smithers suffers severe allergic reactions to the bee sting in this episode, yet in "Burns Verkaufen der Kraftwerk" he was stung by several bees but suffered no problems at all. Bee sting allergies are often triggered on the second instance of being stung, Smithers could have developed his life-threatening allergy after the previous episode.
Despite having returned to the house on a date with Agnes Skinner in "Bart the Fink", in this episode Chalmers apparently required directions to Skinner's house as if he had never been there before. This episode may take place prior to Bart the Fink.
Chief Wiggum loses his hat in the fight with Snake, but in the next chapter of his story he is wearing it again.
Jasper supposedly got a nose job, but he's seen with his regular nose later on.
Snake and Chief Wiggum open the door of Herman's store inwards, but in the scene inside the store, it is open outwards.
Mrs. Glick trips, falls and gets stuck into a trash can during the Nelson segment, but is later seen among the crowd that is laughing at Nelson.